The Jacksonville Jaguars and Indianapolis Colts are set for an important AFC South contest on Sunday. Jacksonville arrives with momentum and are two wins away from locking up the top spot in their division. Indianapolis faces pressure to keep its slim postseason hopes alive despite a massive quarterback change. This preview breaks down the key angles for bettors, and you will get my Jaguars vs Colts prediction before kickoff from Lucas Oil Stadium.
Our Jaguars vs Colts Pick
| Pick: | |
| Confidence: | 4/5 |
Game Snapshot
- Matchup: Jacksonville Jaguars vs Indianapolis Colts
- Date & Time: Sunday, December 28, 2025, 1:00 PM
- Venue: Lucas Oil Stadium, Indianapolis, Indiana
- Broadcast: FOX
Key Storylines
The Jaguars have surged to an 11–4 record, entering Week 17 on a six-game winning streak that has elevated them into postseason contention and put them atop the AFC South. Trevor Lawrence has driven a balanced attack, and key pieces like Jakobi Meyers have provided reliable production since joining the offense. Jacksonville’s defense has also stepped up, providing crucial stops and forcing turnovers at timely points in games.
The Colts enter this game at 8–7 with desperation mounting. A win is required for Indianapolis to keep any realistic playoff hopes alive. Veteran Philip Rivers has returned from retirement under center, providing experience but no wins in his first two outings. The Colts have lost five games in succession, and Indianapolis now faces a difficult final road test against a Jaguars team peaking at the right part of the season.
Quarterback Play
For Jacksonville, Trevor Lawrence’s playmaking has been a catalyst for the team’s recent success. He’s thrown 26 touchdowns while keeping turnovers in check, helping the Jaguars sustain drives and score efficiently. Jacksonville’s offense found a way to put up points on the road against a very good Broncos defense last week and Lawrence deserves some of the credit for that.
On the Indianapolis side, Philip Rivers’ late-season return has provided a veteran presence. But his age and lack of mobility could pose limitations against a Jaguars pass rush that has grown more disruptive as the season has gone on. Rivers’ accuracy and decision making will need to be on point for the Colts to pull an upset here.
Betting Trends & H2H
- The Jaguars defeated the Colts 36-19 in the first meeting between these teams this season.
- The Jaguars are 10-5 against the spread this season.
- Indianapolis is 7-6-2 against the spread going into Week 17.
- The over is 9-6 in Jaguars games this season.
- The Colts are 8-7 to the over this year.
Jaguars vs Colts Model Projection
Final Thoughts
