Los Angeles Clippers vs Portland Trail Blazers Prediction & Picks – 12/26/2025

The LA Clippers and Portland Trail Blazers will square off on Friday night in an interesting matchup in the Western Conference. While the Clippers enter this contest as slight favorites on the road, both clubs are under the .500 mark for the season and they will both be desperate for a win in this contest. Before tip-off from Moda Center, you can continue reading to get my Clippers vs Trail Blazers prediction.

Our Clippers vs Trail Blazers Pick

Game Snapshot

• Matchup: LA Clippers @ Portland Trail Blazers
• Date & Time: Friday, December 26, 2025, 10:00 p.m. ET
• Venue: Moda Center, Portland, Oregon
• Broadcast: Prime Video

Key Storylines

• The Clippers are led by star guard Kawhi Leonard, who scored a season-high 41 points in a recent win over the Houston Rockets and has been the key offensive driver for Los Angeles. James Harden also continues to shoulder playmaking duties and the overall scoring load. However, center Ivica Zubac is out with an ankle sprain, removing a key interior presence and rebounding option from their rotation. Bradley Beal remains out for the season, and Derrick Jones Jr. is also sidelined.
• Portland’s injury report is extensive. Damian Lillard, Jerami Grant, Scoot Henderson, Blake Wesley, and Matisse Thybulle are all confirmed out. Other contributors such as Robert Williams III, Jrue Holiday, and Kris Murray are listed as day-to-day or questionable. Despite that, the Blazers are averaging over 117 points per game with Deni Avdija leading with strong scoring and playmaking numbers, and Shaedon Sharpe has been a bright offensive performer as well.
• Both teams find themselves below .500 and outside of comfortable playoff positioning, with Portland slightly better positioned in standings in 10th place in the West. The Clippers are trying to halt a road losing streak that has seen them drop four away games in a row.

Head-to-Head & Betting Trends

• The Clippers won the first meeting between these teams with a 114-107 win in October where Kawhi Leonard posted 30 points and 10 rebounds.
• Portland is 15-15 against the spread so far this season.
• The Clippers are 10-19 against the spread going into this contest.
• The Clippers have gone under the total in 15 of their first 29 games.
• The over is 18-12 in games involving Portland this year.

Best Player Props to Watch

Clippers vs Trail Blazers Model Projection

Final Thoughts

Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.