Milwaukee Brewers vs Chicago Cubs Game 4 Prediction – 10/9/2025

The Chicago Cubs will host the Milwaukee Brewers in Game 4 of the NLDS on Thursday night. The Cubs are fighting to stay alive and force a Game 5, while the Brewers are trying to close out the series on the road. Chicago avoided elimination with a 4-3 win in Game 3 on Wednesday, but the Cubs are far from safe in this series still. Before these NL Central rivals go at it again, continue reading to get my Brewers vs Cubs Game 4 prediction.

Our Brewers vs Cubs Game 4 Pick

• Pick: Milwaukee Brewers to win
• Confidence: ★★★★☆

Game Snapshot

• Matchup: Milwaukee Brewers vs Chicago Cubs
• Date & Time: Thursday, October 9, 2025, at 9:08 p.m. ET
• Starting Pitchers: Neither side has announced a starter
• Stadium: Wrigley Field, Chicago, IL
• Broadcast: truTV, TBS, HBO Max

Key Storylines

Pitching matchup

Neither team has revealed its starter publicly at the time of this writing. That leaves us with uncertainty but also the expectation that both bullpens will feature prominently in this contest. That could work to the benefit of the Brewers, who have the best bullpen ERA of any team in the postseason at 0.50.

Key Players

Jackson Chourio, Christian Yelich, and Brice Turang are going to have to carry the weight offensively for the Brewers if they want to close this series out on Thursday night. Michael Busch is having a huge series for Chicago, and Pete Crow-Armstrong came through with a two-run single in Game 3 as well. Both bullpens and those offensive players will have a huge impact on which of these teams gets a victory in this contest.

Best Player Props

Betting Trends & H2H

• These teams have gone 8-8 against each other this season between the regular season and playoffs.
• Chicago’s Game 3 win over the Brewers snapped a three-game winning streak for Milwaukee against the Cubs.
• All three games in this NLDS have gone over their totals going into Game 4.
• The home team is 3-0 in this series thus far.

Brewers vs Cubs Game 4 Model Projection

Score Projection: Brewers 4 – Cubs 3
Win Probability: Brewers 54%, Cubs 46%

Final Thoughts

The home team has dominated the proceedings in this series thus far. But I think we could see that change in Game 4. That is especially true if we see a huge share of the pitching done by each bullpen. The Brewers have a superior group of relief pitchers and that could very well set them apart, even in the hostile environment that is Wrigley Field.

Game 4 looks like it is going to be a tight, low-scoring contest. My best bet is for the Brewers to win on the road to clinch this series and set up an NLCS against the winner of the series between the Los Angeles Dodgers and Philadelphia Phillies, which the Dodgers lead coming into Thursday’s play.

Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.