Seattle Seahawks vs Carolina Panthers Prediction & Preview – 12/28/2025

As the 2025 NFL regular season heads into its penultimate weekend, an exciting Week 17 matchup is set between the Seattle Seahawks and the Carolina Panthers. Both clubs have plenty on the line in this Sunday afternoon showdown at Bank of America Stadium in Charlotte. Seattle arrives with a 12-3 record and control of the NFC West, while the 8-7 Panthers lead the NFC South and are fighting for a postseason berth and possibly their first home playoff game in years. Before this game kicks off, you will find my Seahawks vs Panthers prediction below.

Our Seahawks vs Panthers Pick

Game Snapshot

• Matchup: Seattle Seahawks vs Carolina Panthers
• Date & Time: Sunday, December 28, 2025, 1:00 PM Eastern
• Venue: Bank of America Stadium, Charlotte, NC
• Broadcast: CBS

Key Storylines

This game features the NFC’s top seed in Seattle, currently perched at 12-3, against a Panthers squad that has built an 8-7 record and currently leads the NFC South. Seattle’s recent dramatic comeback in overtime against the Los Angeles Rams not only kept their division hopes alive but made them look like a clutch team down the stretch. They may need some more late heroics to get a win here as well.

Carolina enters this contest with a real chance at making the playoffs. A win in the final week of the regular season will lock up the division title for the Panthers no matter what happens this week. But the Panthers will try to stay sharp and build more confidence going into that game with a victory in this contest. After a win in a close game against the Tampa Bay Buccaneers last week, the Panthers’ confidence is soaring entering Week 17.

Quarterback Play

For Seattle, Sam Darnold has been a reliable presence, completing over 67% of his passes with 3,703 yards, 24 touchdowns, and 13 interceptions on the season. He remains a significant part of Seattle’s offensive success, particularly when paired with standout receiver Jaxon Smith‑Njigba, who has been among the league’s more productive wideouts.

Carolina’s playoff hopes rest on the shoulders of quarterback Bryce Young, who has thrown for more than 2,600 yards with 21 touchdown passes and 9 interceptions. While Young has shown he can engineer offense, Carolina’s production pales in comparison to Seattle’s efficiency and explosive plays. But the Panthers could outperform Seattle’s offense at home behind Young nonetheless.

Betting Trends

• Seattle is 10-5 against the spread so far this season.
• Carolina is 9-6 against the spread going into Week 17.
• The Seahawks have gone over the total in 9 of their first 15 games.
• The under has hit in 8 of Carolina’s 15 games this year.

Seahawks vs Panthers Model Projection

Final Thoughts

Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.