The Los Angeles Rams and Jacksonville Jaguars will meet in London on Sunday at the iconic Wembley Stadium. Both of these teams are 4-2 on the season so far and a win here would be huge for the playoff hopes of whoever gets it. Before the action begins from England, continue reading to get my Rams vs Jaguars prediction.
Our Rams vs Jaguars Pick
- Pick: Jacksonville Jaguars +3
- Confidence: ★★★★☆
Game Snapshot
- Matchup: Los Angeles Rams vs Jacksonville Jaguars
- Date & Time: Sunday, October 19, 2025, 9:30 a.m. ET
- Venue: Wembley Stadium, London, England
- Broadcast: NFL Network / NFL+
Rams vs Jaguars Odds
| Spread | Moneyline | Total |
|---|---|---|
| Rams –3 | Rams –150, Jaguars +130 | 44.5 |
Key Storylines
- Rams without Puka Nacua? The Rams’ top receiver suffered an ankle injury in Week 6 and reports suggest he may miss this game or be limited. Nacua already has 54 catches this season and his absence would be a huge blow for Los Angeles.
- Jaguars’ offensive line issues: The Jaguars allowed pressure on Trevor Lawrence 27 times in their Week 6 loss to the Seattle Seahawks, the most in a game since 2022 for a quarterback. That same concern will be magnified against a Rams pass rush led by Defensive Rookie of the Year Jared Verse.
- London calling: The Rams and Jags must overcome traveling across the world, the body clock adjustment, and the less familiar field conditions of Wembley Stadium. The team that adjusts the best will have a great shot at improving to 5-2 for the season.
Quarterback Play
Matthew Stafford has been very good, throwing for 1,684 yards, 12 touchdowns, and just two interceptions. With Nacua’s injury, he may be more reliant on Davante Adams and secondary receivers stepping up. Trevor Lawrence’s success hinges on not turning the ball over. He has five interceptions already this year. If the Rams can bring pressure and force hurried throws, Lawrence may struggle to deliver consistently.
Betting Trends & H2H
- Both of these teams are 4-2 against the spread for the season. They are tied for the best record in the NFL against the spread going into Week 7.
- Both teams are 3-3 on over/unders for the season thus far.
- The Rams are 5-1 all-time against the Jaguars.
Rams vs Jaguars Model Projection
Score Projection: Rams 24 – Jaguars 23
Win Probability: Rams 52%, Jaguars 48%
Final Thoughts
This is going to be a tight game and the fact that it is being played in London should only make things less predictable than usual. The Rams’ top target through the air being compromised from a health standpoint could end up being a major problem for them. I will take the Jags to cover the spread as an underdog, as they have won three of their last four games and could win what is close to a toss-up as far as I’m concerned.
