The Jacksonville Jaguars will head to Empower Field at Mile High to take on the Denver Broncos on Sunday. This Week 16 matchup features two teams with double-digits in the win column with three weeks left to play in the regular season. Denver enters with an NFL-best 12‑2 record and hopes to strengthen its hold on the AFC West and secure the AFC’s top seed. The Jaguars sit at 10‑4 and will try to keep their hopes of earning the top seed alive with a win. Before kickoff from Denver, you will find my Jaguars vs Broncos prediction right here.
Our Jaguars vs Broncos Pick
Game Snapshot
- Matchup: Jacksonville Jaguars vs Denver Broncos
- Date & Time: Sunday, December 21, 2025, 4:05 p.m. ET
- Venue: Empower Field at Mile High, Denver, Colorado
- Broadcast: FOX
Key Storylines
The Broncos have surged to the top of the NFL standings with a 12‑2 record. They have had success on both sides of the ball, and the team is riding an 11-game winning streak into this important AFC game. They have clinched a postseason berth and lock up the top seed in the AFC playoffs with a victory. However, Denver recently placed safety Brandon Jones on injured reserve, which could affect the secondary’s performance against a Jaguars passing attack that has been effective this season.
Jacksonville has been one of the hottest teams in the league, winning five straight games and asserting itself as a contender in the AFC. The Jaguars’ Week 15 win over the New York Jets was highlighted by quarterback Trevor Lawrence’s standout performance. He threw five touchdowns and added a rushing score, propelling the offense to 48 points. Though they are underdogs on the road, Jacksonville has proven capable of scoring in bunches and could challenge Denver in this high‑stakes game.
Quarterback Play
Trevor Lawrence continues to elevate his game, posting impressive yardage and touchdown numbers during Jacksonville’s recent surge. He has thrown for over 3,200 yards, 23 touchdowns, and 11 interceptions and will try to lead his team to a statement win late in the regular season this weekend.
Denver’s Bo Nix has nearly identical numbers to Lawrence this season. Nix has just over 3,200 yards as well, with 23 touchdowns and 9 interceptions. The battle between these two signal‑callers will be crucial, as turnovers and execution under pressure could decide the final result.
Betting Trends
- Jacksonville is 9-5 against the spread through 14 games.
- Denver is 6-7-1 against the spread going into this matchup.
- The Jaguars have gone over the total in 8 of their 14 outings this year.
- The under has cashed in 8 of the 14 games for the Broncos this season.
Jaguars vs Broncos Model Projection
Final Thoughts
