The Dallas Mavericks will host the San Antonio Spurs in the first game of the season for both of these Texas NBA teams. Both of these teams have playoff aspirations this year and we will see two of the best big men in the league face off here. Before San Antonio and Dallas begin their Texas two-step on the court, continue reading to get my Spurs vs Mavericks prediction for Wednesday night.
Our Spurs vs Mavericks Pick
- Pick: Mavericks -2.5
- Confidence: ★★★★☆
Game Snapshot
- Matchup: San Antonio Spurs @ Dallas Mavericks
- Date & Time: Wednesday, October 22, 2025, 9:30 PM ET
- Venue: American Airlines Center, Dallas, TX
- Broadcast: ESPN
Spurs vs Mavericks Odds
| Odds | Spread | Moneyline | Total |
|---|---|---|---|
| Mavericks | -2.5 | -145 | Over 224.5 |
| Spurs | +2.5 | +125 | Under 224.5 |
Key Storylines
- Spurs’ Injury Concerns: San Antonio enters the season opener with several key players sidelined. De’Aaron Fox (hamstring), Jeremy Sochan (calf), Kelly Olynyk (heel), and Lindy Waters III (ankle) are all out. Reigning Rookie of the Year Stephon Castle is day-to-day due to a knee bruise. But the Spurs have Victor Wembanyama back and that could offset all of their other roster challenges.
- Mavericks’ Roster Adjustments: Dallas faces its own injury issues. Kyrie Irving (foot) and Dante Exum (knee) are unavailable for the opener. Center Daniel Gafford is also questionable due to an ankle injury, potentially impacting the Mavericks’ frontcourt depth. But the debut of number one overall pick Cooper Flagg brings an extra layer of excitement and anticipation to the team.
- Victor Wembanyama’s Return: After recovering from deep vein thrombosis and shoulder surgery, Victor Wembanyama is set to make his season debut. Wembanyama’s presence in the paint will be crucial for the Spurs’ defense and rebounding efforts. His scoring both at the rim and from the perimeter will be huge with so many other players missing for San Antonio.
Head-to-Head & Betting Trends
- Recent Matchups: Dallas won three of the four games they played against the Spurs last season. They won the first three meetings of the season against San Antonio before the Spurs grabbed a game to close out their season series.
- Season Openers: The Spurs have a strong record in season openers, winning 18 of their last 22 against Western Conference opponents, indicating their readiness to start the season on a positive note.
- Against the Spread: Three of the four games between these teams this season were decided by double-digits. The point spread might not be a factor if that trend continues in this matchup from Dallas.
Best Player Props to Watch
| Player | Prop |
|---|---|
| Victor Wembanyama | Over 10.5 Rebounds |
| Cooper Flagg | Under 26.5 Points + Rebounds + Assists |
Spurs vs Mavericks Model Projection
- Score Projection: Spurs 112 – Mavericks 118
- Win Probability: Spurs 45%, Mavericks 55%
Final Thoughts
There is always the potential for Wembanyama to have a huge game and for the Spurs to take down the Mavs here. But I don’t think that Wembanyama’s contributions will be enough to offset all of the missing personnel that the Spurs are dealing with. I’ll lay the points with Dallas in this matchup.
