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Philadelphia 76ers vs New York Knicks Pick - 4/1/2025

Philadelphia 76ers vs New York Knicks Prediction: Can Philly Even Series In Game 2?

Updated May 6, 2026 • 4 min read

The New York Knicks will host the Philadelphia 76ers in Game 2 of the Eastern Conference semifinals on Wednesday night. Game 1 of this series sent a loud message, with New York delivering a dominant 137-98 win that exposed major flaws for Philadelphia. But that result counts the same as any other playoff game, and Game 2 on Wednesday night offers a chance for the Sixers to even this series at a game apiece. Before tip-off on Wednesday, continue reading to get my 76ers vs Knicks Game 2 prediction.

76ers vs Knicks Game 2 Pick

  • Pick: 76ers +6.5
  • Confidence: 3 out of 5

Game Snapshot

  • Matchup: Philadelphia 76ers @ New York Knicks
  • Date & Time: Wednesday, May 6, 7:00 PM ET
  • Venue: Madison Square Garden, New York, New York
  • Broadcast: ESPN

Key Storylines

New York enters Game 2 with a 1-0 series lead after opening this series with a blowout against a team that had far fewer days off than the Knicks leading into this series. Their Game 1 performance featured 63.1% shooting from the field, a level that is difficult to maintain, but highlights their offensive ceiling. Jalen Brunson led the charge with 35 points and continues a remarkable run against Philadelphia.

For the Philadelphia 76ers, the focus is on response and adjustments in this game. Joel Embiid is expected to play through an ankle issue, and the team must clean up their turnovers after committing 19 in the opener. Fatigue isn’t likely to be as much of a factor in this game, as the Sixers got the same rest as the Knicks before Game 2, but Philly still needs to clean things up before this contest.

Key Players

New York Knicks

  • Jalen Brunson: Coming off a 35-point performance in Game 1, Brunson has scored at least 35 points in five straight playoff games against Philadelphia. His ability to control the game and score efficiently makes him the centerpiece of New York’s offense.
  • Karl-Anthony Towns: A versatile big man who stretches the floor, Towns creates matchup problems for an out-of-shape Embiid. His perimeter shooting and rebounding presence are key factors in maintaining spacing for the New York Knicks.
  • Mikal Bridges: Provides two-way impact with perimeter defense and scoring. His ability to guard multiple positions helps limit Philadelphia’s wing production.

Philadelphia 76ers

  • Joel Embiid: The former MVP remains the focal point, though he is dealing with an ankle concern. His production in scoring and rebounding will determine whether Philadelphia can compete inside.
  • Tyrese Maxey: A dynamic guard who struggled in Game 1, Maxey must bounce back as a primary scorer and playmaker to relieve pressure on Embiid.
  • Paul George: Led the team with 17 points in Game 1 and offers scoring versatility. Philadelphia needs a more efficient outing from him to keep pace with New York.

Head-to-Head & Betting Trends

  • The Knicks are 3-2 against the 76ers this season after winning Game 1 of this series.
  • The Knicks are 49-41 against the spread this season.
  • Philadelphia is 49-42 against the spread going into this matchup.

76ers vs Knicks Game 2 Model Projection

  • Score Projection: 76ers 115 – Knicks 119
  • Win Probability: 76ers 38%, Knicks 62%

I think we are in for a much closer game than we saw between these teams in Game 1. Philadelphia has the talent to respond, and the Sixers shouldn’t look quite as fatigued compared to their opponent again in Game 2. I’ll take the points with the Sixers, though my expectation is still for the Knicks to find a way to get a win to take a 2-0 series lead in a tense contest at the world’s most famous arena.

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Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.

Affiliate Disclosure ATS.io uses affiliate links. If you sign up through a link on this page, we may earn a commission at no additional cost to you. Rankings are based on hands-on testing and published criteria, and affiliate relationships do not determine placement.
Tags: New York Knicks, Philadelphia 76ers
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