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Detroit Tigers vs St. Louis Cardinals Prediction - 5/19/2025

St. Louis Cardinals vs Detroit Tigers Prediction: Who Wins On Sunday Night Baseball?

Updated April 5, 2026 • 3 min read

The St. Louis Cardinals and Detroit Tigers wrap up their early-season series on Sunday, with Detroit holding a clear edge after an offensive outburst in the previous game. The Tigers powered their way to an 11-6 win on Saturday, showcasing a lineup capable of producing runs in bunches. Both clubs enter this contest with identical 4-4 records, but the tone of the series has been set by Detroit’s bats and St. Louis’ inconsistent pitching. Before the first pitch is thrown on Sunday Night Baseball, continue reading to find my Cardinals vs Tigers prediction below.

Cardinals vs Tigers Pick

  • Pick: Detroit Tigers -1.5
  • Confidence: 3 out of 5

Game Snapshot

  • Matchup: St. Louis Cardinals vs Detroit Tigers
  • Date & Time: Sunday, April 5, 2026, 7:20 PM
  • Starting Pitchers: Kyle Leahy vs Keider Montero
  • Stadium: Comerica Park, Detroit, MI
  • Broadcast: Peacock

Key Storylines

  • Detroit exploded for 11 runs in the previous game, powered by multiple home runs and timely hitting.
  • St. Louis continues to struggle with run prevention, allowing 7 runs from a starter in the last outing. The Cards have been outscored 15-6 in this series so far.
  • Both teams sit at 4-4, but Detroit has a stronger home profile at 2-0, while the Cards have lost their first two road games of the 2026 season.

Pitching Matchup

  • Kyle Leahy enters with a 0-1 record and a 7.20 ERA across 5 innings, along with a 2.00 WHIP.
  • Leahy has allowed 8 hits already in limited action, raising concerns about traffic on the bases.
  • Keider Montero is making his first start of the 2026 season and will try to make an immediate impact for the Tigers.

Key Players

  • Jordan Walker is coming off a grand slam performance and drove in 5 runs in the last game.
  • Gleyber Torres contributed with a home run and multiple hits for Detroit on Saturday.
  • Dillon Dingler leads the Tigers with 7 RBI coming into this matchup.

Recent Team Streaks

  • The Cardinals have dropped the first two games of this series against the Tigers.
  • St. Louis is searching for its first road win of the season, while the Tigers try to stay undefeated at home.

Cardinals vs Tigers Model Projection

  • Score Projection: St. Louis Cardinals 4 – Detroit Tigers 6
  • Win Probability: St. Louis Cardinals 45%, Detroit Tigers 55%

Detroit enters this game with a clear offensive edge after hammering St. Louis pitching throughout the series. The Cardinals have shown flashes at the plate, highlighted by Walker’s breakout performance, but their inability to limit opposing hitters remains a major concern. With Leahy carrying a high ERA and allowing consistent contact, the Tigers are well-positioned to generate scoring opportunities once again. My best bet here is to lay the runline with the Tigers in the finale of this weekend series.

More Baseball Betting Resources

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Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.

Affiliate Disclosure ATS.io uses affiliate links. If you sign up through a link on this page, we may earn a commission at no additional cost to you. Rankings are based on hands-on testing and published criteria, and affiliate relationships do not determine placement.
Tags: Detroit Tigers, St. Louis Cardinals
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