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Seattle Mariners vs San Diego Padres Pick - 5/16/2025

San Diego Padres vs Seattle Mariners Prediction: Padres Look to Sweep Seattle Again

Updated May 17, 2026 • 4 min read

San Diego heads into Sunday night looking for a sweep after taking the first two games of the series in Seattle. The Padres have already gone 5-0 against the Mariners this season and continue to get strong pitching, timely hitting, and steady late-inning relief work against them. Seattle enters the finale of this Padres vs Mariners series trying to avoid another frustrating offensive showing against one of the better pitching staffs in baseball.

Our Padres vs Mariners Pick

  • Pick: Padres Moneyline +135
  • Confidence: 3.5 out of 5

Game Snapshot

  • Matchup: San Diego Padres vs Seattle Mariners
  • Date & Time: Sunday, May 17, 2026, 11:20 PM ET
  • Starting Pitchers: Lucas Giolito vs George Kirby
  • Stadium: T-Mobile Park, Seattle, WA
  • Broadcast: Peacock

Key Storylines

  • San Diego has won all 5 meetings against Seattle this season.
  • The Padres have allowed only 4 total runs across the first 2 games of this series.
  • Seattle continues to deal with injuries, including Cal Raleigh remaining sidelined with an oblique injury.
  • San Diego bullpen arms Jason Adam, Adrian Morejon, and Mason Miller have been excellent in close games.
  • The Mariners have dropped 3 of their last 4 games and continue to struggle offensively against quality pitching.

Pitching Matchup

George Kirby has been Seattle’s most reliable starter this season. The right-hander enters with a 5-2 record and a 2.84 ERA while limiting walks at an elite rate. Kirby attacks the strike zone early and rarely gives hitters free passes, which keeps Seattle competitive even when the offense cools off. His ability to work deep into games is a major factor for a Mariners club that has leaned heavily on its bullpen in recent weeks.

Giolito is making his first appearance of the season for San Diego. It will be interesting to see how he performs in his first action of the 2026 campaign. And while San Diego has a slightly higher team ERA than the Mariners this season, you wouldn’t know it from the games that these two teams have played agianst each other this year.

Key Players

  • Xander Bogaerts, Padres: Team leader with 7 home runs and 23 RBI while batting above .250.
  • Gavin Sheets, Padres: Coming off another productive series and continues to provide power in the middle of the order.
  • Miguel Andujar, Padres: Batting near .300 and delivering key extra-base hits during this road trip.
  • George Kirby, Mariners: Seattle’s ace enters with a 2.84 ERA and only 14 walks allowed in 57 innings.
  • Luke Raley, Mariners: Leads Seattle with 10 home runs and 27 RBIs.
  • Randy Arozarena, Mariners: Batting above .300 and remains Seattle’s most dangerous all-around hitter.

Betting Trends & H2H

  • San Diego is 5-0 against Seattle so far this season.
  • Four of San Diego’s five wins over the Mariners this year have come by at least two runs.
  • San Diego is 14-8 on the road so far this season.
  • Seattle comes into this contest with a 12-13 record at their home ballpark.

Padres vs Mariners Model Projection

  • Score Projection: Padres 4 – Mariners 3
  • Win Probability: Padres 52%, Mariners 48%

Seattle’s offense has lacked consistency, especially with injuries affecting the middle of the lineup. Giolito’s strikeout ability creates problems for a Mariners club that already swings and misses at a high rate. With San Diego carrying the hotter bullpen and entering with confidence after two straight wins in Seattle, the value sits on the underdog price as far as I’m concerned. I’ll take the Padres to complete a season sweep of the Mariners before moving onto bigger and better things this season.

More Baseball Betting Resources

  • All Baseball Betting Picks
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Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.

Affiliate Disclosure ATS.io uses affiliate links. If you sign up through a link on this page, we may earn a commission at no additional cost to you. Rankings are based on hands-on testing and published criteria, and affiliate relationships do not determine placement.
Tags: San Diego Padres, Seattle Mariners
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