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New York Yankees vs Cleveland Guardians Pick - 4/22/2025

New York Yankees vs Cleveland Guardians Prediction, Preview & Odds – 6/9/2026

Updated June 9, 2026 • 4 min read

The New York Yankees and Cleveland Guardians continue their series on Tuesday night at Progressive Field after New York claimed a 7-5 extra-innings victory in the opener. The Yankees enter the game at 39-26 and remain firmly in the American League playoff picture, while Cleveland sits at 37-31 and is trying to keep pace in the AL Central race. Tuesday’s pitching matchup features Gerrit Cole against Slade Cecconi, creating a significant edge on paper for New York.

Our Yankees vs Guardians Prediction

  • Pick: Yankees Moneyline
  • Confidence: 4 out of 5

New York Yankees vs Cleveland Guardians Model Projection

  • Score Projection: Yankees 5 – Guardians 3
  • Win Probability: Yankees 61%, Guardians 39%

The biggest factor in this game is the starting pitching matchup. Cole has posted a 2.00 ERA and 0.89 WHIP across 18 innings this season, while Cecconi enters with a 4.92 ERA and 1.43 WHIP. Cleveland’s offense has been below league average for much of the season, ranking behind New York in most key offensive categories.

The Yankees also hold advantages in runs scored, home runs, OPS, ERA, and overall run prevention. New York averages more than five runs per game while Cleveland sits closer to four. The Guardians can certainly compete at home, but the statistics point toward the Yankees having the stronger lineup and the better starter. New York is in a favorable position to secure another road victory in this one.

Game Snapshot

  • Matchup: New York Yankees vs Cleveland Guardians
  • Date & Time: Tuesday, June 9, 2026, 6:40 PM Eastern Time
  • Starting Pitchers: Gerrit Cole vs Slade Cecconi
  • Stadium: Progressive Field, Cleveland, OH
  • Broadcast: TBS

New York Yankees vs Cleveland Guardians Same Game Parlay

3-Leg Same Game Parlay

  • Yankees Moneyline -137
  • Gerrit Cole Over 5.5 Strikeouts +124
  • Ben Rice Over 1.5 Total Bases -105

Parlay Odds: +440

The Yankees have the edge on the mound with Cole, who has dominated through his first few starts. Rice has emerged as one of New York’s most productive hitters, carrying a batting average above .300 with significant power production. Combining a Yankees victory with a solid strikeout performance from Cole and continued production from Rice creates an attractive same-game parlay ticket.

New York Yankees vs Cleveland Guardians Home Run Prop

Ben Rice to Hit a Home Run +275

Rice has been one of New York’s hottest hitters, entering the game with a .304 batting average and .641 slugging percentage. He has already developed into a major power threat and draws a favorable matchup against Cecconi, who has allowed nine home runs this season. At better than 2-to-1 odds, the value is appealing.

Betting Trends & H2H

  • Yankees lead the current series 1-0 after Monday’s 7-5 victory.
  • These teams are 2-2 against each other during the 2026 season.
  • New York is 20-14 on the road this season.
  • Cleveland is 17-15 at home this season.
  • New York has won 6 of its last 10 games.
  • Cleveland is 4-6 across its last 10 games.
  • The under is 32-29-4 in Yankees games this season.
  • Cleveland is 34-34 in the over/under market this season.

Stat Comparison

CategoryYankeesGuardians
Batting Average.242.231
OPS.763.690
wOBA.336.309
wRC+11496
Team ERA3.273.77
xFIP3.803.85

The statistical comparison reinforces New York’s advantage entering Tuesday’s game. The Yankees have been the superior offensive club, generating more power and run production while also posting stronger run prevention numbers. With Gerrit Cole facing Slade Cecconi, the starting pitching edge further strengthens New York’s outlook.

In fairness, the xFIP numbers between these teams are incredibly close, which is a better indicator of pure pitching ability than ERA. But Cole being on the bump for this game should widen that gap in this individual contest. I’ll take the Yankees on the moneyline in Northeast Ohio on Tuesday.

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Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.

Affiliate Disclosure ATS.io uses affiliate links. If you sign up through a link on this page, we may earn a commission at no additional cost to you. Rankings are based on hands-on testing and published criteria, and affiliate relationships do not determine placement.
Tags: cleveland guardians, New York Yankees
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