Los Angeles Dodgers vs San Francisco Giants Prediction: Ohtani Takes the Mound For LA

The rivalry between the Los Angeles Dodgers and San Francisco Giants continues Wednesday night at Oracle Park, with Game 2 of their series following a surprising opener. San Francisco grabbed a 3-1 win in the opener, striking early and leaning on strong pitching to hold off a potent Dodgers lineup. Now the focus shifts to a Dodgers vs Giants matchup that heavily favors Los Angeles on paper, as Shohei Ohtani takes the mound against Tyler Mahle.

Dodgers vs Giants Pick

• Pick: Dodgers -1.5
• Confidence: 4 out of 5

Game Snapshot

• Matchup: Los Angeles Dodgers vs San Francisco Giants
• Date & Time: Wednesday, April 22, 2026, 9:45 PM
• Starting Pitchers: Shohei Ohtani vs Tyler Mahle
• Stadium: Oracle Park, San Francisco, CA
• Broadcast: MLB.tv

Key Storylines

• The Giants took Game 1 behind early offense and bullpen execution.
• The Dodgers enter at 16-7 with the top offense in MLB, but they have dropped 3 of their last 4 games going into this contest.
• San Francisco is just 10-13 but has won 4 of its last 5 games.

Pitching Matchup

Ohtani has been dominant early in the season, posting a 2-0 record with a 0.50 ERA across 18 innings. He has struck out 18 while allowing just 7 hits and no home runs. He has also consistently worked deep into games, completing 6 innings in each outing.

Mahle, on the other hand, has struggled to find rhythm. Through 18.2 innings, he owns a 7.23 ERA, allowing 24 hits and 6 home runs while walking 12 batters. His inability to limit traffic on the bases has put pressure on a Giants bullpen that was excellent in the series opener but may not sustain that nightly.

Key Players

• Shohei Ohtani has been elite on the mound and remains a threat at the plate as well.
• Andy Pages is hitting around .366 with strong run production.
• Max Muncy leads the Dodgers with 8 home runs.
• Casey Schmitt and Luis Arraez provide contact hitting for San Francisco, with Arraez batting .302 on the season.
• Willy Adames adds power with a team-high 3 home runs, but the Giants lineup lacks depth behind him at times.

Betting Trends & H2H

• The Giants are 1-0 against the Dodgers this season.
• The under hit in the first game between these teams this year.
• The under is 12-11 in Dodgers games this year.
• The Giants are 10-10-3 in the over/under market this year.

Dodgers vs Giants Model Projection

• Score Projection: Dodgers 6 – Giants 3
• Win Probability: Dodgers 68%, Giants 32%

While San Francisco showed it can compete in the opener, this matchup presents a very different challenge. Ohtani’s current form gives Los Angeles a strong edge from the first pitch, and the Dodgers’ lineup remains one of the most productive groups in baseball. Facing a struggling Mahle, this is a spot where that offense can break through early and build a lead. I’ll lay the runline with the Dodgers in this contest, as they should even this series at a game apiece.

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Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.

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