The series between the Chicago Cubs and Milwaukee Brewers will come down to Game 5 on Saturday at American Family Field in Milwaukee. The Cubs forced this finale with a 6–0 shutout win in Game 4. The home team has won all four games of this series so far and the Brewers will try to continue that trend to advance to the NLCS. Before the first pitch in Saturday’s Game 5, you can find my Cubs vs Brewers Game 5 prediction below.
Our Cubs vs Brewers Game 5 Pick
- Pick: Brewers Moneyline
- Confidence: ★★★☆☆
Game Snapshot
- Matchup: Chicago Cubs vs Milwaukee Brewers
- Date & Time: Saturday, October 11, 2025, 8:08 PM ET
- Starting Pitchers: TBA
- Stadium: American Family Field, Milwaukee, WI
- Broadcast: TBS / truTV / HBO Max
Key Storylines
Pitching matchup
No starters have been officially announced yet for this game. But no matter who starts this game on the mound, we should see both bullpens get heavily involved. Both starters will likely be on short leashes. Names like Shota Imanaga of the Cubs and Jacob Misiorowski of the Brewers have been floated as pitchers who could feature prominently in this game. But some bettors may want to wait for confirmation before locking any bets in for this contest.
Key Players
- Ian Happ: Struggling earlier in the postseason, Happ delivered a three-run home run in Game 4 that immediately shifted the momentum of that contest. If Happ can carry that into Game 5, he could give the Cubs the edge here.
- Michael Busch: Busch has already hit multiple homers in this series and his power gives the Cubs a dangerous bat to rely on.
- Christian Yelich and Jackson Chourio: For Milwaukee, the top of the order must function for them to win this game. Yelich’s veteran bat and Chourio’s speed will be critical to their success.
- Bullpens: With elimination on the line, the two bullpens will be so important in determining this game’s outcome. Milwaukee has had the better bullpen over the course of the postseason so far, but anything can happen in a one-game elimination scenario.
Recent Team Streaks
- The Cubs have won the last two games of the series, including a shutout in Game 4.
- Chicago is 0-2 on the road this postseason.
- Milwaukee is 2-0 at home in the 2025 playoffs.
Best Player Props
| Player | Prop |
|---|---|
| Ian Happ | Over 1.5 Total Bases |
| Michael Busch | Under 1.5 Total Bases |
| Jackson Chourio | Over 0.5 Home Runs |
Betting Trends & H2H
- The Cubs hold a 9-8 lead in their season series with the Brewers, including both the regular season and postseason.
- Milwaukee is 54-29 at home across the regular season and playoffs.
- Chicago enters this game with a 42-41 road record.
- The home team is 4-0 in this series so far.
Cubs vs Brewers Game 5 Model Projection
Score Projection: Cubs 4 – Brewers 5
Win Probability: Cubs 42%, Brewers 58%
Final Thoughts
The home team has had the upper hand throughout this series so far and I expect that to be the case again in this winner-take-all matchup. The Brewers will have a ton of crowd noise in their corner here. More importantly, they have the best record in the league this season and they should get the job done at home to set up an NLCS matchup with the Los Angeles Dodgers.
