The Ole Miss Rebels will take on the Oklahoma Sooners in an SEC matchup in college football on Saturday. Both of these teams enter this game in the top 15 in the rankings and a win would be huge for the College Football Playoff hopes of whichever team can secure it. Before kickoff from Norman, continue reading to get my Ole Miss vs Oklahoma prediction.
Our Ole Miss vs Oklahoma Pick
- Pick: Oklahoma Sooners -5.5
- Confidence: 3/5
Game Snapshot
- Matchup: Ole Miss Rebels vs Oklahoma Sooners
- Date & Time: Saturday, October 25, 2025, 12:00 p.m. ET
- Venue: Gaylord Family–Oklahoma Memorial Stadium, Norman, OK
- Broadcast: ABC
Key Storylines
Ole Miss has ranked among the country’s more explosive passing offenses this season under Lane Kiffin. The Rebels rank 19th nationally in “explosive pass rate” and will try to air it out successfully with Trinidad Chambliss this week as well. But Oklahoma’s defense is beginning to assert itself as one of the best in all of college football.
The health and performance of quarterback John Mateer is crucial for Oklahoma. He transferred from Washington State and has been recovering from an injury that hindered his performance against Texas two weeks ago. A healthy Mateer gives the Sooners a chance to win this game and compete for a playoff spot. Ole Miss’ defense was torched by Georgia last week and will need to step up to avoid a second straight loss.
Quarterback Play
Oklahoma’s John Mateer appears to be back close to full health and is surrounded by weapons. Mateer has thrown for 1,567 yards, seven touchdowns, and six interceptions. He is also dangerous running with the ball, which gives the Sooners an edge in sustaining drives and converting red-zone opportunities.
Ole Miss’ Trinidad Chambliss must keep pace with Mateer in a game where any turnover or misfire may shift momentum Oklahoma’s way. Chambliss was impressive against Georgia last week but was let down by the Ole Miss defense.
Betting Trends
- Ole Miss is 4-3 against the spread so far this season.
- Oklahoma is 3-3-1 against the spread going into Saturday’s action.
- All seven of Oklahoma’s games have stayed under their totals this year.
- Ole Miss has gone 4-3 to the over going into this contest against Oklahoma.
Ole Miss vs Oklahoma Model Projection
Score Projection: Oklahoma 28 – Ole Miss 21
Win Probability: Oklahoma 65%, Ole Miss 35%
Final Thoughts
The defense of the Oklahoma Sooners should be the difference maker in this contest. The Sooners rank second to Ohio State in terms of scoring defense in FBS this season. They are one of just two teams in the country giving up under 10 points per game for the year. We should see the Sooners make life tough on Chambliss and the Ole Miss offense and Oklahoma should cover the spread at home in a huge game in the SEC.
