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louisville vs smu prediction and preview

SMU Mustangs vs Louisville Cardinals Prediction: SMU Looks to Move Above the Bubble

Updated March 10, 2026 • 3 min read

The ACC Tournament continues Wednesday afternoon with an intriguing clash between SMU and Louisville at Spectrum Center in Charlotte. Both teams bring explosive offenses into this meeting, and their earlier contest this season produced plenty of points. SMU enters the game with a 20-12 record and is coming off an 86-69 victory against Syracuse in the tournament opener. Louisville, meanwhile, sits at 22-9 overall and has won two straight games going into this SMU vs Louisville contest.

Our SMU vs Louisville Pick

Pick:

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Confidence: 3 out of 5

Game Snapshot

  • Matchup: SMU Mustangs vs Louisville Cardinals
  • Date & Time: Wednesday, March 11, 6:30 PM ET
  • Venue: Spectrum Center, Charlotte, North Carolina
  • Broadcast: ACC Network

Key Storylines

One of the biggest storylines entering this game is revenge. SMU defeated Louisville 95-85 during the regular season, a game that highlighted the Mustangs’ ability to push the pace and generate scoring from several guards. Louisville struggled defensively that night and will look to tighten things up this time. But Louisville won the first meeting between these teams this season, and it will be interesting to see who wins the rubber match.

Another factor is current form. SMU has had an inconsistent stretch, dropping several games before beating Syracuse in the tournament opener. Louisville has been steadier, winning three straight games entering postseason play. Their perimeter shooting has been particularly strong as they hope to be peaking at the right time.

Key Players

Louisville Cardinals

  • Ryan Conwell leads Louisville with 18.7 points per game while adding 4.7 rebounds and 2.6 assists. He also leads the ACC in made three-pointers per game at 3.4 and provides the Cardinals with a reliable scoring option in late-game situations. He will be more important than usual with Mikel Brown Jr. out for the ACC Tournament.
  • J’Vonne Hadley contributes across the stat sheet with scoring and rebounding production. His physical play inside helps Louisville maintain a solid rebounding edge in many games.

SMU Mustangs

  • Boopie Miller leads SMU in scoring with 19.4 points per game. His ability to attack the rim and create shots off the dribble makes him the engine of the Mustangs’ offense.
  • Jaron Pierre Jr. averages over 17 points per game and provides another scorer in the backcourt. When he and Miller are both hitting shots, SMU can put pressure on any defense.

Stat Comparison

StatSMULouisville
Points per game85.085.9
Points allowed per game78.172.5
Team Field Goal %49%47%
Rebounds Per Game37.638.7
Assists Per Game17.117.4

Head-to-Head & Betting Trends

  • These teams have split their two regular-season meetings this year.
  • SMU comes into this matchup with a 12-18-1 record against the spread.
  • Louisville is 16-15 against the spread before the start of their conference tournament.

SMU vs Louisville Model Projection

Score Projection:

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Win Probability:

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Final Thoughts

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Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.

Affiliate Disclosure ATS.io uses affiliate links. If you sign up through a link on this page, we may earn a commission at no additional cost to you. Rankings are based on hands-on testing and published criteria, and affiliate relationships do not determine placement.
Tags: louisville cardinals, SMU Mustangs
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