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Los Angeles Dodgers vs San Diego Padres Prediction - 6/10/2025

Los Angeles Dodgers vs San Diego Padres Prediction: Rivalry Rematch After 1-0 Series Opener

Updated May 19, 2026 • 4 min read

The National League West race continues Tuesday night as the Los Angeles Dodgers head back into Petco Park for the second game of this week’s series against the San Diego Padres. Monday’s opener turned into a tight pitching duel, with San Diego grabbing a 1-0 win behind seven scoreless innings from Michael King. The rematch sets up differently, though, with the Dodgers sending Emmet Sheehan to the mound against Padres right-hander Griffin Canning. More scoring will be expected in this Dodgers vs Padres rematch, though it will be hard to get a more competitive game this time around.

Our Dodgers vs Padres Pick

  • Pick: Over 8.5
  • Confidence: 4 out of 5

Game Snapshot

  • Matchup: Los Angeles Dodgers vs San Diego Padres
  • Date & Time: Tuesday, May 19, 2026, 9:40 PM ET
  • Starting Pitchers: Emmet Sheehan vs Griffin Canning
  • Stadium: Petco Park, San Diego, CA
  • Broadcast: MLB.tv

Key Storylines

  • The Padres shut out the Dodgers 1-0 on Monday despite Los Angeles putting runners on base late in the game.
  • The Dodgers own one of MLB’s best offenses with a .262 team batting average and 248 runs scored, but they were held scoreless on the road on Monday night.
  • San Diego has won 4 straight games and continues to stay at the top of the NL West standings, entering this game with a 1.5 game lead over the Dodgers atop the division.
  • Griffin Canning enters with a 10.64 ERA across his first 11 innings this season and he will be tested again by a potent Dodgers offense here.
  • Los Angeles has won 5 of its last 6 games despite Monday’s loss.

Pitching Matchup

Emmet Sheehan has delivered decent enough innings for the Dodgers this season, posting a 3-1 record with a 4.54 ERA and 49 strikeouts across 41.2 innings. His strikeout ability gives Los Angeles a strong edge in this matchup, especially against a Padres lineup that has struggled at times against power pitching. Sheehan also comes into this start after a solid outing against San Francisco in which he allowed 2 runs over 6 innings.

Canning has had a difficult start to his Padres tenure after returning from injury. Through 11 innings, he owns a 10.64 ERA with a 2.18 WHIP, allowing heavy traffic on the bases nearly every inning. His recent outing against Milwaukee was especially rough, as he surrendered 6 runs before finishing the second inning. Facing the Dodgers lineup is a far tougher assignment.

Key Players

  • Andy Pages: Continues to anchor the Dodgers offense with a .299 batting average and 41 RBI.
  • Freddie Freeman: Producing another strong season with elite contact numbers and extra-base power.
  • Mookie Betts: Gives Los Angeles another dangerous bat at the top of the lineup.
  • Fernando Tatis Jr.: Still searching for more consistency at the plate despite strong overall talent.
  • Gavin Sheets: Leads San Diego with 9 home runs and has carried much of the recent offensive production.
  • Xander Bogaerts: Leads the Padres with 23 RBI.

Betting Trends & H2H

  • The Padres are 1-0 this season against the Dodgers.
  • The first game of this series went under the total with 1 total run scored.
  • The Dodgers are 14-9 on the road this season after Monday’s loss.
  • The Padres hold a 14-10 record at home.

Dodgers vs Padres Model Projection

  • Score Projection: Dodgers 6 – Padres 3
  • Win Probability: Dodgers 64%, Padres 36%

Monday’s opener showed how tight this rivalry can become when elite pitching takes over. Tuesday’s game will be different, as both pitchers are vulnerable to giving up more runs than what we saw on Monday night. Sheehan has been far steadier than Canning, and Los Angeles carries one of baseball’s deepest lineups into a favorable matchup against a pitcher struggling badly with command and contact management. But I think both sides will do their share of scoring here, and my best bet for this matchup is the over.

More Baseball Betting Resources

  • All Baseball Betting Picks
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Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.

Affiliate Disclosure ATS.io uses affiliate links. If you sign up through a link on this page, we may earn a commission at no additional cost to you. Rankings are based on hands-on testing and published criteria, and affiliate relationships do not determine placement.
Tags: Los Angeles Dodgers, San Diego Padres
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