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Philadelphia 76ers vs New York Knicks Pick - 4/1/2025

Philadelphia 76ers vs New York Knicks Prediction: Game 1 a Huge Opportunity For New York

Updated May 3, 2026 • 4 min read

The second round of the NBA Playoffs opens Monday night with a clash between the Philadelphia 76ers and New York Knicks at Madison Square Garden. Philadelphia arrives riding the high of a stunning comeback series win over Boston, closing with three straight victories and a dominant Game 7 performance. New York handled its first-round opponent with authority and enters this matchup rested, confident, and favored at home. Here, I break down 76ers vs Knicks Game 1 and make my prediction in the betting markets.

76ers vs Knicks Game 1 Pick

  • Pick: Knicks -7.5
  • Confidence: 3 out of 5

Game Snapshot

  • Matchup: Philadelphia 76ers @ New York Knicks
  • Date & Time: Monday, May 4, 8:00 PM ET
  • Venue: Madison Square Garden, New York, New York
  • Broadcast: NBC, Peacock

Key Storylines

Philadelphia’s dramatic turnaround against Boston has reshaped how this team is viewed. The return of Joel Embiid transformed the Philadelphia 76ers into a far more dangerous group, and their ability to win three straight elimination games speaks to how high their ceiling is as a team. However, this is a quick turnaround, and fatigue could be a factor, especially against a Knicks team that wrapped up its series earlier.

New York enters as the more consistent and balanced side. The Knicks have built their success on efficient offense, strong rebounding, and a deep rotation that can wear teams down. Playing at Madison Square Garden gives them an added edge, and their strong regular-season record at home reinforces their status as a legitimate contender in the East.

Key Players

New York Knicks

  • Jalen Brunson: Averaging 26.3 points in the postseason, Brunson drives the offense and thrives in big moments. His shot creation and control of pace are central to the New York Knicks‘ success.
  • Karl-Anthony Towns: Posting 18.7 points and 11.3 rebounds per game in the playoffs, Towns provides interior and perimeter scoring that can challenge Philadelphia’s frontcourt.
  • OG Anunoby: Anunoby is key in limiting opposing wings and he is second to Brunson in points per game this postseason for New York.

Philadelphia 76ers

  • Joel Embiid: Averaging 28.0 points and 9.0 rebounds in the playoffs, Embiid remains the focal point for Philly. His health and stamina will be closely watched after returning late in the first round.
  • Tyrese Maxey: Maxey’s scoring and perimeter shooting are critical to keeping pace with the Knicks. He could have a favorable matchup against Jalen Brunson in this series.
  • Paul George: George stepped up in a big way in the late stages of the first-round series against the Celtics and Philly needs more of the same from him in Game 1 of this series.

Head-to-Head & Betting Trends

  • These teams are 2-2 against each other this season.
  • The road team went 4-0 in games between the Knicks and Sixers during the regular-season.
  • The Knicks are 48-41 against the spread going into this matchup.
  • Philadelphia is 49-41 entering this contest.

76ers vs Knicks Game 1 Model Projection

  • Score Projection: Philadelphia 76ers 104 – New York Knicks 113
  • Win Probability: Philadelphia 76ers 38%, New York Knicks 62%

The key factor in Game 1 is situational. Philadelphia is playing its best basketball of the season, but doing so on short rest after an emotional Game 7 win will be a challenge. That type of tight turnaround often leads to slower starts, especially on the road in a high-energy environment like Madison Square Garden. New York’s depth, rebounding, and fresher legs should allow it to control the pace and gradually pull away. I recommend laying the points with the Knicks in this series opener.

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Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.

Affiliate Disclosure ATS.io uses affiliate links. If you sign up through a link on this page, we may earn a commission at no additional cost to you. Rankings are based on hands-on testing and published criteria, and affiliate relationships do not determine placement.
Tags: New York Knicks, Philadelphia 76ers
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