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Philadelphia 76ers vs Boston Celtics Prediction - 3/6/2025

Philadelphia 76ers vs Boston Celtics Game 1 Prediction: Can Philly Compete Without Embiid?

Updated April 17, 2026 • 4 min read

The Philadelphia 76ers and Boston Celtics will open their first-round NBA playoff series on Sunday at TD Garden. Philadelphia enters off a play-in victory over the Orlando Magic, while Boston comes in rested and heavily favored. The 76ers earned their spot with a strong showing led by Tyrese Maxey, while the Celtics bring one of the league’s most balanced teams into the postseason after a 56-win campaign. Here, I break down this matchup and make my 76ers vs Celtics Game 1 prediction before the action begins.

76ers vs Celtics Game 1 Pick

  • Pick: Boston Celtics -12.5
  • Confidence: 4 out of 5

Game Snapshot

  • Matchup: Philadelphia 76ers @ Boston Celtics
  • Date & Time: Sunday, April 19, 1:00 PM ET
  • Venue: TD Garden, Boston, Massachusetts
  • Broadcast: ABC

Key Storylines

Philadelphia arrives with recent game action under its belt after a 109-97 win in the play-in round, where Maxey erupted for 31 points. That performance highlights how dangerous the 76ers can be when their lead guard controls the game. Still, the quick turnaround into a road playoff opener is far from ideal, especially against a deeper Boston group and a much better team than the Orlando team Philly beat in the first round.

Boston finished the regular season 56-26 and ranked near the top of the league on both ends of the floor. Their consistency has been the defining factor, while Philadelphia hovered around league average in most categories. Health remains a concern for the 76ers, particularly with Joel Embiid out, while the Celtics have Jayson Tatum back on the floor and are close to full health.

Key Players

Boston Celtics

  • Jaylen Brown: Averaging 28.7 points per game, Brown drives Boston’s offense with efficient scoring and strong perimeter play.
  • Derrick White: Posting about 5.4 assists per game, White helps control tempo and contributes on both ends with perimeter defense and outside shooting.
  • Jayson Tatum: The Celtics had a great year without Tatum on the floor for most of the season. Now that he is back on the floor, the Celtics look like they could be the best team in the league once again.

Philadelphia 76ers

  • Tyrese Maxey: Fresh off a 31-point performance in the play-in, Maxey is the engine of the offense and a high-volume scorer.
  • Paul George: Added 16 points in the play-in and offers shot creation along with veteran leadership.
  • Andre Drummond: Recorded a double-double in the play-in and anchors the glass, which will be key against Boston’s frontcourt, especially with Embiid out.

Stat Comparison

Category76ersCeltics
Points per game115.9114.9
Team Field Goal %46%47%
Rebounds per game43.646.4
Assists per game24.624.6

Head-to-Head & Betting Trends

  • Season series split 2-2, with both teams stealing a game on the road.
  • The Celtics are 49-33 against the spread this season, the second-best ATS record in the NBA this year.
  • Philadelphia is 44-39 against the spread entering the first round of the playoffs.

76ers vs Celtics Model Projection

  • Score Projection: Philadelphia 76ers 107 – Boston Celtics 121
  • Win Probability: Philadelphia 76ers 32%, Boston Celtics 68%

Boston enters this opener with advantages in depth, efficiency, and rest. Their ability to generate consistent offense while maintaining defensive discipline gives them a clear edge, especially at home where they have been dominant. Philadelphia’s path to an upset depends heavily on Maxey sustaining elite scoring output and getting meaningful contributions from supporting players. But I don’t think Philly will get enough from its supporting cast to keep this game close. I’ll lay the points with the Celtics in Game 1.

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Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.

Affiliate Disclosure ATS.io uses affiliate links. If you sign up through a link on this page, we may earn a commission at no additional cost to you. Rankings are based on hands-on testing and published criteria, and affiliate relationships do not determine placement.
Tags: Boston Celtics, Philadelphia 76ers
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