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Memphis Grizzlies vs Detroit Pistons Prediction - 4/5/2025

Memphis Grizzlies vs Detroit Pistons Prediction: Can Pistons Get Second Win In Two Nights?

Updated March 13, 2026 • 3 min read

The Memphis Grizzlies travel to Detroit on Friday night for a meeting with one of the NBA’s hottest teams. Detroit has surged to the top tier of the Eastern Conference behind an elite defense and the playmaking of Cade Cunningham, while Memphis continues to deal with injuries and depth issues. The Grizzlies enter the game after a sixth straight loss last night and have struggled to keep pace with healthier opponents. Here, I break down whether they can play better against Detroit with my Grizzlies vs Pistons prediction.

Game Snapshot

  • Matchup: Memphis Grizzlies @ Detroit Pistons
  • Date & Time: Friday, March 13, 2026, 7:30 PM ET
  • Venue: Little Caesars Arena, Detroit, Michigan
  • Broadcast: NBA League Pass

Key Storylines

Detroit enters the night with one of the best records in the league at 47-18. The Pistons have turned into a defensive powerhouse this season while still scoring at a strong rate. Their balanced lineup and strong rebounding presence make them difficult to handle inside.

Memphis, on the other hand, has been short-handed for weeks and continues to lean on younger players and role pieces. The Grizzlies are just 23-42 overall and 11-21 on the road. They have also dropped six straight games, including a 120-112 loss to Dallas in their most recent outing. Despite the losing streak, Memphis has remained competitive offensively, averaging over 115 points per game this season.

Key Players

Detroit Pistons

  • Cade Cunningham – The All-Star guard leads Detroit with about 25.3 points and 9.6 assists per game. Cunningham controls the offense and consistently creates high-quality shots for teammates.
  • Jalen Duren – The athletic center averages roughly 10.4 rebounds per game and provides strong interior scoring. His presence on the glass is a major factor in Detroit’s ability to limit second chances.
  • Isaiah Stewart – Stewart adds toughness in the paint with strong defense and shot blocking. He helps anchor a Pistons defense that ranks among the best in points allowed.

Memphis Grizzlies

  • Ty Jerome – Jerome is one of many players who has been called into a bigger role this season for the Grizzlies than he may have been expecting, due to all of the trades and injuries that have handicapped their roster. Jerome is questionable for this game, but his presence would be huge for the Grizzlies.
  • Cam Spencer – Spencer has taken on a larger playmaking role, leading Memphis with about 5.6 assists per game while helping organize the offense during injuries.

Stat Comparison

StatMemphisDetroit
Points per game115.8117.2
Points allowed per game118.3109.6
Team Field Goal %46%48%
Rebounds per game43.745.8
Assists per game28.726.8

Head-to-Head and Betting Trends

  • Detroit won the only previous meeting between these teams this season, 114-106.
  • Detroit holds a 33-32 ATS record this season.
  • Memphis is 30-35 ATS this season.

Grizzlies vs Pistons Pick and Model Projection

  • Score Projection: Memphis Grizzlies 104 – Detroit Pistons 122 ATS PRO
  • Pick: Pistons -15.5 ATS PRO
  • Confidence: 1 out of 5 ATS PRO
  • Win Probability: Memphis 28%, Detroit 72% ATS PRO

Detroit enters the game with clear advantages in health, defense, and recent form. The Pistons have built their season around a balanced attack led by Cade Cunningham and a physical frontcourt that controls rebounds. That formula has produced a dominant home record and a defense that consistently holds opponents well below their scoring averages.

The only thing giving me pause here is the fact that the Pistons are on the second game of a back-to-back here after they crushed the Philadelphia 76ers on Thursday. I recommend laying the points with Detroit, but the back-to-back lowers my confidence rating significantly in this game.

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Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.

Affiliate Disclosure ATS.io uses affiliate links. If you sign up through a link on this page, we may earn a commission at no additional cost to you. Rankings are based on hands-on testing and published criteria, and affiliate relationships do not determine placement.
Tags: Detroit Pistons, Memphis Grizzlies
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