Xavier Musketeers vs Creighton Bluejays Pick & Prediction – 1/21/2026

The Xavier Musketeers and Creighton Bluejays will renew their Big East rivalry on Wednesday night, which could have meaningful implications for conference positioning as the league season moves deeper into January. Creighton enters this game with an 11‑8 overall record and a 5‑3 mark in conference play, while Xavier sits at 11‑7 overall and 3‑4 in Big East action. Creighton hosts this affair at the CHI Health Center Omaha, where the Bluejays have been strong all season long. Before this game begins in Nebraska, keep reading to get my Xavier vs Creighton prediction on the court.

Our Xavier vs Creighton Pick

Game Snapshot

• Matchup: Xavier Musketeers @ Creighton Bluejays
• Date & Time: Wednesday, January 21, 2026, 7:00 p.m. ET
• Venue: CHI Health Center Omaha, Omaha, Nebraska
• Broadcast: FS1

Key Storylines

Creighton has been an inconsistent but dangerous squad in conference play, owning an 11‑8 record and 5‑3 mark in the Big East. They’re coming off a competitive loss to Providence in a game where they scored in bunches, but struggled defensively late. Jasen Green and Josh Dix have provided offensive sparks when Creighton has needed production, but nobody is averaging over 12.5 points per game for the Bluejays this year. Creighton’s home-court advantage has been a strength, as they have been tough to beat at CHI Health Center Omaha with an 8-2 home record.

Xavier has found some rhythm recently, riding a two‑game winning streak into this matchup. Tre Carroll has paced the Musketeers with a team‑leading 16.7 points per game, while Malik Messina‑Moore’s facilitation has helped them share the ball effectively. Xavier’s recent surge has come against Butler and Providence, but consistency remains a question, especially on the defensive end at times. They’ll need to maintain their recent offensive efficiency and limit turnovers to stay within striking distance on the road.

Head‑to‑Head & Betting Trends

• Xavier is 23-21 all-time against Creighton.
• Creighton won the first meeting between these teams this season in December by a score of 98-57.
• Xavier is 9-9 against the spread this season.
• Creighton enters this game with an 8-11 record against the spread this year.
• The over is 12-6 in games involving Xavier so far this season.
• The under is 11-8 in Creighton’s games this year.

Xavier vs Creighton Model Projection

Final Thoughts

Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.