The San Francisco 49ers will battle the Seattle Seahawks in the NFC Divisional Round on Saturday, with the Seahawks hosting the contest at Lumen Field. Seattle earned the top seed and home-field advantage throughout the NFC playoffs after a 14-3 regular season and a Week 18 win over San Francisco. The 49ers bounced back from that Week 18 loss and arrive off a gritty Wild Card victory over the defending champion Eagles. Who will win this NFC West rivalry game and earn a spot in the NFC Championship Game? Continue reading to get my 49ers vs Seahawks prediction for the Divisional playoffs.
Our 49ers vs Seahawks Pick ATS PRO
| Pick: | |
| Confidence: | 3/5 |
Game Snapshot
- Matchup: San Francisco 49ers @ Seattle Seahawks
- Date & Time: Saturday, January 17, 2026, Time TBD
- Venue: Lumen Field, Seattle, WA
- Broadcast: Network TBD
49ers vs Seahawks Odds
| Odds | Line |
|---|---|
| Spread | Seahawks -7.5 |
| Moneyline | Seahawks -340, 49ers +270 |
| Total | About 45.5 |
Key Storylines
Seattle earned the NFC’s top seed by winning 14 games and beating San Francisco 13-3 late in final week of the regular season to secure home-field advantage throughout the NFC playoffs. That victory was a product of Seattle’s stout defense and effective running game, with Zach Charbonnet’s touchdown and strong contributions from Kenneth Walker III leading the way. The Seahawks enter the Divisional round with confidence, buoyed by a 6-2 home record and a defense capable of limiting explosive offenses.
The 49ers arrive off a 23-19 road win against the Eagles in the Wild Card round, showcasing a ton of toughness in a close contest. Brock Purdy delivered key throws, and a creative trick play helped seal the victory. However, San Francisco suffered a significant blow with tight end George Kittle’s torn Achilles, which removes one of the team’s most dynamic offensive weapons from their playoff run. The 49ers also face travel and rest disadvantages here against a Seahawks team that earned a first-round bye.
Quarterback Play
Sam Darnold has managed Seattle’s offense effectively this season with 4,048 passing yards, 25 touchdowns, and 14 interceptions. The question for Darnold is whether he can deliver in the playoffs after struggling in big games time and time again in the past. Avoiding interceptions will be huge for his hopes of leading his team to a win here.
Brock Purdy has led San Francisco’s offense with efficiency and poise, distributing the ball to playmakers and minimizing mistakes. Purdy threw two interceptions against the Eagles in the Wild Card round, but he also came through when the Niners needed him the most and the Niners will trust that he can do it again in this matchup.
Betting Trends & H2H
- These teams are 1-1 against each other this season, with the road team winning both of those games.
- The 49ers are 11-6-1 against the spread so far this season.
- Seattle is 12-5 against the spread going into their playoff opener.
- Seattle went over the total in 9 of their 17 regular-season games.
- The over is 10-7-1 in Niners games this year.
49ers vs Seahawks Model Projection ATS PRO
Final Thoughts ATS PRO
