New Orleans Saints vs Tennessee Titans Predictions – 12/28/2025

The New Orleans Saints will head to Nissan Stadium to take on the Tennessee Titans on Sunday afternoon. Entering this game with 5 wins and 10 losses, the Saints have won three games in a row and will look for a fourth straight here. The Titans enter at 3-12, though they snapped a long losing streak with a convincing 26-9 win over the Kansas City Chiefs in their most recent outing. Which team will get the victory in this matchup? Continue reading to get my Saints vs Titans prediction for Week 17 of the NFL season.

Our Saints vs Titans Pick

Game Snapshot

• Matchup: New Orleans Saints vs Tennessee Titans
• Date & Time: Sunday, December 28, 2025, 1:00 PM
• Venue: Nissan Stadium, Nashville, TN
• Broadcast: CBS

Key Storylines

Both teams find themselves out of playoff contention with records that include 10 or more losses on both sides. A Saints victory not only extends their winning streak but would also throw another interesting wrinkle into the discussion about rookie quarterbacks in the NFL this season, as both quarterbacks in this game are in their first NFL seasons. New Orleans’ defense has shown improvement, forcing turnovers and limiting scoring opportunities, while the offense has found rhythm under Tyler Shough.

Tennessee has struggled to score consistently this season, ranking near the bottom of the league in passing. Their persistent offensive inefficiency remains a primary concern, especially after drafting a quarterback first overall in the most recent draft. The Titans are looking to build on their recent win over the Kansas City Chiefs, which knocked the defending AFC champions out of playoff contention.

Quarterback Play

Saints’ quarterback Tyler Shough has put together solid performances down the stretch, showing growth in decision-making and accuracy. He is doing a great job of creating opportunities for top target Chris Olave, who has consistently stretched defenses. Shough winning this game for his team would cast further doubt on the Titans’ decision to draft Ward first overall.

Cam Ward has been one of many problems with the Titans’ offense this season. He has operated with limited weapons around him, but he has just 14 touchdown passes through Tennessee’s first 15 games. He must rely on Tony Pollard on the ground and timely throws to Chig Okonkwo and Elic Ayomanor to keep drives alive.

Betting Trends

• New Orleans is 7-8 against the spread going into Week 17.
• The Titans are 7-7-1 against the spread so far this season.
• The Saints have stayed under the total in 11 of their 15 games.
• The over has hit in 9 of the Titans’ first 15 games this year.

Saints vs Titans Model Projection

Final Thoughts

Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.