The New York Knicks and Minnesota Timberwolves will meet in one of the games of the night in the NBA on Wednesday. New York has yet to lose on their home floor and will try to stay unbeaten at Madison Square Garden. But the Timberwolves could be getting their top star back from injury to help them against New York. Before tip-off from the world’s most famous arena, continue reading to get my Timberwolves vs Knicks prediction.
Our Timberwolves vs Knicks Pick
- Pick: New York Knicks -4.5
- Confidence: ★★★★☆
Game Snapshot
- Matchup: Minnesota Timberwolves @ New York Knicks
- Date & Time: Wednesday, November 5, 2025, 7:30 PM ET
- Venue: Madison Square Garden, New York, New York
- Broadcast: ESPN
Key Storylines
The Knicks enter this game with a four‑game home winning streak to start the season. They most recently dispatched the Washington Wizards 119‑102 at home. They were powered by a 33‑point, 13‑rebound performance from Karl‑Anthony Towns and a strong contribution from OG Anunoby (16 points, five steals). New York has won two games in a row and will try to pass a big test at home in this matchup.
The Timberwolves are also in decent form, fresh off a 125‑109 win over the Brooklyn Nets on the road. They have also won two games in a row, albeit against the abysmal Nets and Charlotte Hornets. Now the Timberwolves will aim for a third straight road win and their best road win of the young season so far.
The biggest storyline going into this game might be the health of Anthony Edwards of the Timberwolves. Minnesota’s star has missed a large portion of the season so far but is questionable for tonight’s game. His return would be huge for the Wolves against a quality opponent.
There is also intrigue surrounding any meeting between these teams after their blockbuster trade before last season. New York sent Julius Randle and Donte DiVincenzo to Minnesota in exchange for Karl-Anthony Towns. Both teams seem to have benefited from that move, but there will always be interest in those players facing their former teams.
Head‑to‑Head & Betting Trends
- This is the first time these teams have met this season.
- Minnesota is 5-2 to the over through seven games so far this year.
- The Timberwolves are just 2-5 against the spread this season.
- New York is 4-3 against the spread on the year.
- The Knicks have gone over the total in four of their seven games.
Best Player Props to Watch
| Player | Prop |
|---|---|
| Jalen Brunson (NYK) | Over 27.5 points |
| Karl‑Anthony Towns (NYK) | Over 21.5 points |
| Anthony Edwards (MIN) | Under 25.5 points (if he plays) |
Timberwolves vs Knicks Model Projection
Score Projection: Minnesota 110 – New York 117
Win Probability: New York 65%, Minnesota 35%
Final Thoughts
I think that the Knicks hold the upper hand in this matchup at home. If Anthony Edwards was fully healthy, things might be different. But with Edwards at best playing hurt in this contest, I’ll go with the Knicks to win and cover the spread to improve to 5-0 on their home floor for the season.
