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charlotte hornets vs philadelphia 76ers prediction and preview

Charlotte Hornets vs Philadelphia 76ers Prediction – 10/25/2025

Updated October 25, 2025 • 3 min read

The Charlotte Hornets will travel to Philadelphia to face the 76ers on Saturday night at Xfinity Mobile Arena. Both teams enter the game with a 1-0 record and will try to get a second straight victory over an Eastern Conference opponent here. Before tip-off from Philly, continue reading to get my breakdown of this game, including my Hornets vs 76ers prediction.

Hornets vs 76ers Pick

  • Pick: Charlotte Hornets +6
  • Confidence: ★★☆☆☆

Game Snapshot

  • Matchup: Charlotte Hornets @ Philadelphia 76ers
  • Date & Time: Saturday, October 25, 2025, 7:30 PM ET
  • Venue: Xfinity Mobile Arena, Philadelphia, PA
  • Broadcast: NBA League Pass

Key Storylines

The Hornets showcased a potent offense in their season opener, defeating the Brooklyn Nets 136-117. Brandon Miller led the charge with 25 points, while LaMelo Ball contributed 20 points and a team-high eight assists. The team displayed remarkable depth, with nine players scoring in double digits, setting a franchise record. They shot an impressive 53.3% from the field and 47.2% from beyond the arc. Charlotte will try to replicate that performance against the Sixers tonight.

The 76ers edged out the Boston Celtics 117-116 in their opener. Rookie VJ Edgecombe had a historic debut, scoring 34 points. That was the third-highest scoring NBA debut in history. Tyrese Maxey added 40 points in the win. But the team struggled with turnovers, committing 17 in the game. Joel Embiid’s performance was underwhelming, scoring just four points on 1-of-9 shooting. He didn’t play during crunch time and there will always be questions about his health until he is out there more consistently.

The injury report for this game has Paul George listed as out of action for this contest. George is expected to make his season debut within the next few days. But his absence could help the Hornets to hang around in this game from Philly.

Head-to-Head & Betting Trends

  • Recent Meetings: The 76ers have won 12 of the last 14 matchups against the Hornets.
  • Against the Spread (ATS): Both teams covered the spread in their first games of the season.
  • Over/Under (O/U): Both teams went over the total in their season openers.
  • Home/Road Splits: This is the first home game of the season for the Sixers and the first road game of the year for the Hornets.

Best Player Props to Watch

PlayerProp
Brandon MillerOver 20.5 Points
LaMelo BallOver 7.5 Assists
VJ EdgecombeOver 3.5 Three-Pointers Made

Hornets vs 76ers Model Projection

Score Projection: Charlotte Hornets 117 – Philadelphia 76ers 111

Win Probability: Charlotte Hornets 55%, Philadelphia 76ers 45%

Final Thoughts

Both of these teams exceeded expectations in their season openers. But I think the Hornets have a real shot to win outright as an underdog on Saturday night. The Sixers should see some regression from Edgecombe in this contest and the Hornets have the shooters to keep this game close. I’ll take the points with Charlotte in what could be the upset of the night in the NBA if Charlotte plays like they did on Wednesday.


Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.

Affiliate Disclosure ATS.io uses affiliate links. If you sign up through a link on this page, we may earn a commission at no additional cost to you. Rankings are based on hands-on testing and published criteria, and affiliate relationships do not determine placement.
Tags: Charlotte Hornets, Philadelphia 76ers
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