Memphis and UAB will do battle in the American Athletic Conference on Saturday. The Tigers are undefeated at 6-0 on the season and they will try to maintain their spot in the top 25 with a win against a UAB team that in the midst of a coaching change. Before kickoff from Birmingham, you can get my Memphis vs UAB prediction below.
Our Memphis vs UAB Pick
- Pick: Memphis –21.5
- Confidence: ★★★★☆
Game Snapshot
- Matchup: Memphis Tigers vs UAB Blazers
- Date & Time: Saturday, October 18, 2025, 4:00 p.m. ET
- Venue: Protective Stadium, Birmingham, AL
- Broadcast: ESPN2
Memphis vs UAB Odds
| Odds | Line | Moneyline | Total |
|---|---|---|---|
| Memphis | –21.5 | –2000 | Over 62.5 |
| UAB | +21.5 | +1000 | Under 62.5 |
Key Storylines
- Battle for the Bones: The trophy for this rivalry game is a 94‑pound bronze rack of ribs and it adds some extra flair to this rivalry. Memphis has had the upper hand in recent meetings between these teams. UAB leads the all‑time series, but that isn’t expected to mean much on Saturday.
- Coaching shakeup in Birmingham: UAB fired Trent Dilfer following a rough 2‑4 start and three straight losses by double digits. Offensive coordinator Alex Mortensen now serves as interim head coach. That kind of disruption in the middle of the season could help things in a bizarre way, or it could just further the misery for this team as the year goes on.
- Memphis’ balance and momentum: The Tigers have looked dialed in this season. They’re 6‑0 both straight up and ATS so far, showing consistency in just about every way and even beating Arkansas out of the SEC.
Quarterback Play
Memphis quarterback Brendon Lewis anchors an offense that can beat defenses through both the air and on the ground. Through six games, he has thrown for 1,269 yards and 8 touchdowns, while also being a threat as a runner. Memphis’ offense is incredibly balanced and that should give them the upper hand in this game.
UAB’s Jalen Kitna has been his team’s offensive centerpiece. He leads the team in passing yards with 1,776 yards through the air. Kitna has 10 touchdown passes and four interceptions. He’s supported by receivers like Iverson Hooks and backs like Jevon Jackson. But Kitna will have to play one of his best games of his career if UAB is going to pull off an upset here.
Betting Trends & H2H
- Memphis is 6‑0 against the spread this season.
- UAB is just 2‑4 against the spread going into this week.
- UAB has gone over the total in five of their first six games.
- Memphis is 3-3 on over/unders this season.
- UAB is 10-7 all-time against Memphis, but Memphis has won the last three meetings between these programs.
Memphis vs UAB Model Projection
- Score Projection: Memphis 42 – UAB 17
- Win Probability: Memphis 92%, UAB 8%
Final Thoughts
Memphis is undefeated going into this game and I expect them to remain undefeated after this game. The Tigers should prey on the porous defense of UAB, while the Blazers’ offense will struggle to move the ball through the air against a Memphis defense that is allowing just 16.2 points per game. I’ll lay the points with Memphis in what should be a lopsided game in Birmingham.
