Cincinnati Reds vs Milwaukee Brewers Prediction – 9/28/2025

The Cincinnati Reds and Milwaukee Brewers will face off on the final day of the 2025 MLB season on Sunday afternoon. The Reds have everything to play for in this contest. A win or a Mets loss would send Cincinnati to the postseason, while the Brewers have locked up the top seed in the upcoming playoffs. Before this important game begins in Milwaukee on Sunday, continue reading to get my Reds vs Brewers prediction.

Our Reds vs Brewers Pick

• Pick: Reds Moneyline
• Confidence: ★★★☆☆

Game Snapshot

• Matchup: Cincinnati Reds vs Milwaukee Brewers
• Date & Time: Sunday, September 28, 2025, 3:10 p.m. ET
• Starting Pitchers: Brady Singer (Reds) vs Freddy Peralta (Brewers)
• Stadium: American Family Field, Milwaukee, WI
• Broadcast: FDSWI and FDSOH

Key Storylines

This is a win-and-in game for Cincinnati. The Reds’ 7–4 win on Saturday kept them tied with the Mets at 83–78. Cincinnati holds the tiebreaker over the Mets for the final NL Wild Card spot. One more victory or a Mets loss sends them to the postseason. Milwaukee doesn’t have anything to play for in this game after locking up the NL’s top seed. That said, the Brewers will want to end the regular season on a strong note and not give a wounded opponent an easy win.

Pitching matchup

Milwaukee hands the ball to Freddy Peralta, who has enjoyed yet another breakout campaign. He arrives with a 17–6 record, a 2.68 ERA, and a 1.07 WHIP. At home, his splits are especially strong. He’ll look to control a Reds lineup that got to Milwaukee’s staff on Saturday. Cincinnati counters with Brady Singer, who has compiled a 14–11 record with a 3.95 ERA and a 1.23 WHIP. He’s been solid, but this will be a tough test as he tries to bring his team a win in a huge spot.

Recent team streaks

Milwaukee has lost five of its last six, slowing down now that their postseason status has been secured. Cincinnati has won three games in a row going into this matchup. They are playing with desperation and will try to use that to their advantage again here.

Best Player Props

Betting Trends & H2H

• Milwaukee holds a 7-5 lead in their season series against the Reds.
• The Reds have won three straight meetings with the Brewers going into this game.

Reds vs Brewers Model Projection

Score Projection: Cincinnati 5 – Milwaukee 4

Win Probability: Reds 53%, Brewers 47%

Final Thoughts

I think that the Cincinnati Reds will secure a playoff berth with a win on the road in this contest. I don’t think that the Brewers will push Peralta deep into this game since they already know they are going to be the top seed in the postseason. Cincinnati should take advantage of some extended bullpen innings for Milwaukee and the Reds should win as a slight underdog on the road to lock up a place in October.

Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.