The BYU Cougars will travel to Boulder to face the Colorado Buffaloes in a Big 12 matchup at Folsom Field on Saturday. BYU comes into this game ranked in the top 25 and will look to keep it that way by defeating Deion Sanders’ struggling squad. Here, I break down this matchup in the Big 12 and give you my BYU vs Colorado prediction for Saturday’s game.
Our BYU vs Colorado Pick
- Pick: BYU -6.5
- Confidence: ★★★★☆
Game Snapshot
- Matchup: BYU Cougars vs Colorado Buffaloes
- Date & Time: Saturday, September 27, 2025, 10:15 p.m. ET
- Venue: Folsom Field, Boulder, CO
- Broadcast: ESPN
BYU vs Colorado Odds
| Betting Line | Odds |
|---|---|
| Spread | BYU -6.5 |
| Moneyline | BYU -250, Colorado +200 |
| Total | 50.5 |
Key Storylines
- BYU’s Undefeated Start: The Cougars enter the game with a perfect 3-0 record, having recently defeated East Carolina 34-13. Their balanced offense and stout defense have been key to their success.
- Colorado’s Quarterback Play: Kaidon Salter has reclaimed the starting role for the Buffaloes, leading the team with both his arm and legs. His dual-threat capabilities make him a constant threat on the field. But he hasn’t been as effective as coach Deion Sanders would have liked going into the season and that needs to change for Colorado to have success here.
- Defensive Matchup: BYU’s defense has been dominant, ranking sixth in third-down defense and 13th in red zone defense. Colorado will need to find ways to sustain drives and convert in critical situations to keep up with the Cougars.
Quarterback Play
Kaidon Salter’s return to form against Wyoming is a positive sign for Colorado. However, BYU’s defense has been exceptional at limiting third-down conversions. Salter has also had a hard time against teams that are not Delaware and Wyoming and that could be a major concern against another Big 12 opponent.
BYU has received steady play from Bear Bachmeier so far this season. He has four touchdown passes and has yet to throw an interception. If he can continue to play mistake-free football, the Cougars will be expected to remain unbeaten.
Betting Trends & H2H
- BYU’s Trends: BYU has covered the spread in three straight games to open the season.
- Colorado’s Trends: The Buffaloes are 1-2-1 against the spread early in the year.
- Head-to-Head: In last season’s Alamo Bowl, BYU defeated Colorado 36-14, showcasing their dominance. But Colorado sat out several key players in that game and looks completely different this year.
BYU vs Colorado Model Projection
- Score Projection: BYU 30 – Colorado 20
- Win Probability: BYU 65%, Colorado 35%
Final Thoughts
BYU enters this game as the stronger team, with a balanced offense and a defense that excels in critical situations. Kaidon Salter should struggle against a quality opponent again in this game and I will lay the points with BYU against an overmatched Colorado offense.
