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Cincinnati Reds vs Milwaukee Brewers Pick - 4/5/2025

Cincinnati Reds vs Milwaukee Brewers Prediction – 9/27/2025

Updated September 27, 2025 • 3 min read

The Cincinnati Reds and Milwaukee Brewers will face off on Saturday at American Family Field in Milwaukee. Both teams are eager to secure a victory given that there are playoff implications on both sides in this game. The Reds are currently in the final National League Wild Card position and will try to hold onto that spot here. Milwaukee is trying to lock up home-field advantage throughout the playoffs. Here, I analyze this matchup and give you my Reds vs Brewers prediction for Saturday.

Our Reds vs Brewers Pick

  • Pick: Reds Moneyline
  • Confidence: 4/5

Game Snapshot

  • Matchup: Cincinnati Reds vs Milwaukee Brewers
  • Date & Time: Saturday, September 27, 2025, 7:15 PM ET
  • Starting Pitchers: Andrew Abbott (Reds) vs Robert Gasser (Brewers)
  • Stadium: American Family Field, Milwaukee, WI
  • Broadcast: FOX

Key Storylines

Pitching Matchup

Andrew Abbott (9-7, 2.80 ERA) takes the mound for the Reds. The left-hander has been a consistent performer this season, with a solid ERA and a high strikeout rate. In his last outing, Abbott delivered 4.2 scoreless innings against the Chicago Cubs and he will look for a similar performance tonight.

Robert Gasser (0-1, 6.00 ERA) will start this game for the Brewers. This will be Gasser’s second start of the season and he will need to prove himself against a potent Reds lineup. In his previous appearance, he pitched three innings, allowing two earned runs on one hit against the St. Louis Cardinals.

Recent Team Streaks

  • Reds: The Reds have won their last two games, including a crucial 3-1 victory over the Brewers on Friday. Their pitching staff has been performing well, with a 1.88 ERA over the last 10 games.
  • Brewers: The Brewers lost their last game but they have been dominant at home. They have a 51-28 record at American Family Field. They are still in the driver’s seat for the top seed in the National League and will look to bounce back in this matchup.

Best Player Props

PlayerProp
Gavin LuxOver 1.5 Total Bases
Elly De La CruzOver 0.5 Home Runs
Christian YelichOver 0.5 RBIs
Spencer SteerOver 0.5 Home Runs

Betting Trends & H2H

  • Brewers: Milwaukee is 51-28 at home this season.
  • Reds: Cincinnati is 37-42 on the road for the year.
  • Head-to-Head: The Brewers lead the season series 7-4 over the Reds, though Cincinnati won the first game of this series last night.

Reds vs Brewers Model Projection

  • Score Projection: Reds 5 – Brewers 4
  • Win Probability: Reds 56%, Brewers 44%

Final Thoughts

The Brewers have been the better team of these two throughout this season. But Cincinnati is fighting for its playoff life right now and they have the talent necessary to get a win in this spot. The Reds’ starting pitching advantage should be the deciding factor here, as I’ll take the Reds to win this game as a moneyline underdog to move to within one win or Mets loss of making the playoffs.


Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.

Affiliate Disclosure ATS.io uses affiliate links. If you sign up through a link on this page, we may earn a commission at no additional cost to you. Rankings are based on hands-on testing and published criteria, and affiliate relationships do not determine placement.
Tags: Cincinnati Reds, Milwaukee Brewers
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