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new york yankees vs chicago white sox prediction and preview

Chicago White Sox vs New York Yankees Prediction – 9/25/2025

Updated September 25, 2025 • 3 min read

The New York Yankees will continue their push for the AL East title as they host the Chicago White Sox at Yankee Stadium on Thursday night. With a 90-68 record, the Yankees have won seven of their last eight games and are tied for first place in the division. They will look to get one last win over the struggling White Sox before heading into their final series of the season. Here, I have broken down this American League matchup and you can find my White Sox vs Yankees prediction below.

Our White Sox vs Yankees Pick

  • Pick: Yankees -2.5
  • Confidence: 4/5

Game Snapshot

  • Matchup: Chicago White Sox vs New York Yankees
  • Date & Time: Thursday, September 25, 2025, 7:05 PM ET
  • Starting Pitchers: Davis Martin (CHW) vs Carlos Rodon (NYY)
  • Stadium: Yankee Stadium, Bronx, NY
  • Broadcast: YES Network, CHSN

Key Storylines

Pitching Matchup

  • Davis Martin (White Sox): The right-hander has a 7-10 record with a 4.03 ERA and 1.27 WHIP. He has struck out 99 batters in 138.1 innings this season. Martin will face a potent Yankees lineup that leads the majors in home runs and runs scored.
  • Carlos Rodón (Yankees): Rodón enters this start with a 17-9 record with a 3.04 ERA and 1.06 WHIP. He has accumulated 198 strikeouts over 189.1 innings. Rodón’s walk numbers are high but he has made up for that by allowing just 128 hits in his 189.1 innings of work.

Key Players

  • Aaron Judge (Yankees): Judge has been on fire, hitting his 50th and 51st home runs of the season in the previous game. He leads the majors with a .328 batting average and has 109 RBI.
  • Miguel Vargas (White Sox): Vargas has shown some power this season, hitting 15 home runs and driving in 52 runs. He will need to step up to provide support for the White Sox offense.

Recent Team Streaks

  • Yankees: The Yankees have won seven of their last eight games and are tied for first place in the AL East. Their offense is firing on all cylinders, and their pitching staff has been solid of late.
  • White Sox: The White Sox have lost 10 of their last 11 games and have reached 100 losses for the third consecutive season. Their offense ranks near the bottom of the league, and their pitching staff has struggled.

Best Player Props

PlayerProp
Aaron JudgeOver 0.5 home runs
Carlos RodónOver 7.5 strikeouts
Miguel VargasOver 0.5 RBIs

Betting Trends & H2H

  • The Yankees hold a 5-1 lead in their season series with the White Sox this year.
  • This is the final game scheduled between these teams this season.
  • Four of New York’s five wins over the White Sox have come by two runs or more.

White Sox vs Yankees Model Projection

  • Score Projection: Yankees 6 – White Sox 2
  • Win Probability: Yankees 71.4%, White Sox 28.6%

Final Thoughts

The Yankees are playing very well down the stretch this season and should continue to do so in this game. I will lay the 2.5-run runline with the Yankees here, as they should crush the White Sox to keep the pressure on the Blue Jays. New York could very well end the day in sole possession of the AL East lead.


Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.

Affiliate Disclosure ATS.io uses affiliate links. If you sign up through a link on this page, we may earn a commission at no additional cost to you. Rankings are based on hands-on testing and published criteria, and affiliate relationships do not determine placement.
Tags: Chicago White Sox, New York Yankees
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