The Ohio State Buckeyes will travel across the country to take on the Washington Huskies at Husky Stadium on Saturday afternoon. Both teams come into this game at 3-0, with Ohio State being ranked number one in the country and Washington still unranked. This game represents a chance for Ohio State to remain national title favorites, while Washington could move right into the top 25 with a victory. Before this game begins in Seattle, continue reading to get my Ohio State vs Washington prediction.
Our Ohio State vs Washington Pick
- Pick: Ohio State −8
- Confidence: ★★★★☆
Game Snapshot
- Matchup: Ohio State Buckeyes vs Washington Huskies
- Date & Time: Saturday, September 27, 2025, 3:30 PM ET
- Venue: Husky Stadium, Seattle, WA
- Broadcast: CBS / Paramount+
Ohio State vs Washington Odds
| Spread | Moneyline | Total |
|---|---|---|
| Ohio State −8 | Ohio State −320, Washington +260 | 51.5 |
Key Storylines
- Ohio State’s defense has been dominant so far. They have allowed 5.3 points per game and held the preseason number-one Texas Longhorns to just seven points in their season opener. The Buckeyes’ defense will try to dominate another opponent in this contest.
- Washington’s offense under QB Demond Williams Jr. has been efficient and explosive. He’s completing over 73% of his passes, has thrown six touchdowns and no interceptions. He will try to lead the Washington offense to another strong performance here, but this will be by far his biggest test of the season so far.
- For Ohio State, QB Julian Sayin has thrown for 779 yards, eight touchdowns, and three interceptions in three games. The wide receiver duo of Jeremiah Smith and Carnell Tate is producing at a high level for the top team in America. But the star of the show is the defense for Ohio State and that means plenty of margin for error for the Buckeyes’ offense.
- Home-field advantage in Seattle could be a factor. Husky Stadium tends to be loud and challenging for road teams. This is also the first road game of the season for the Buckeyes and they will need to perform in a hostile environment for the first time.
Betting Trends & H2H
- Ohio State is 2-0-1 against the spread early in the season.
- Washington has covered the spread in two of its first three games.
- Two of Ohio State’s first three games have gone under their totals.
- All three games for the Huskies this season have gone over their totals.
Ohio State vs Washington Model Projection
Score Projection: Ohio State 31 – Washington 20
Win Probability: Ohio State 68%, Washington 32%
Final Thoughts
I want to believe that the Ohio State Buckeyes will struggle in their first road game of the season. But I’m not sure that we are going to see that play out. Ohio State’s defense is built to travel and win in hostile environments and I don’t see that defense laying an egg in this game just because they are on the road. I am going to lay the points with Ohio State in this matchup, as they should shut down the Huskies in one of the biggest games of the week in the Big Ten.
