The Los Angeles Dodgers and Arizona Diamondbacks will play the second game of a three-game series on Wednesday. This is a big game for both teams and will impact the results of both the National League West race and the NL Wild Card race as well. Before these postseason contenders take the field, continue reading to see what my Dodgers vs Diamondbacks prediction is for tonight.
Our Dodgers vs Diamondbacks Pick
- Pick: Diamondbacks Moneyline
- Confidence: 3/5
Game Snapshot
- Matchup: Los Angeles Dodgers vs Arizona Diamondbacks
- Date & Time: Wednesday, September 24, 2025, 9:40 PM ET
- Starting Pitchers: Blake Snell vs Ryne Nelson
- Stadium: Chase Field, Phoenix, AZ
- Broadcast: SportsNet LA, Dbacks.TV
Key Storylines
Pitching matchup
Blake Snell has been one of the Dodgers’ more consistent arms this season. He has a 2.44 ERA across his starts in 2025. Coming into this game, he offers a high-ceiling lefty option for Los Angeles. Ryne Nelson has quietly been solid for Arizona, with a 3.34 ERA and 123 strikeouts. He’s not as flashy as Snell, but he gives Arizona a chance to keep the game close.
The bullpen for both sides is under stress. The Dodgers’ relief corps recently blew a 4-0 lead on Tuesday night, while Arizona’s pen has had its share of late-game issues during their wild-card push. The ability to hold leads late will be critical.
Recent team streaks
The Dodgers, while leading their division, have left the door open for the San Diego Padres late in the season. The Dodgers have lost two games in a row and are just 1.5 games ahead of San Diego in the division title race. Arizona suddenly has life in its Wild Card chase after winning three games in a row. They are just a game back of the New York Mets for the final playoff spot in the NL.
Best Player Props
| Player | Prop |
|---|---|
| Shohei Ohtani | Under 1.5 Total Bases |
| Teoscar Hernández | Under 1.5 Total Bases |
| Ryne Nelson | Over 5.5 Strikeouts |
Betting Trends & H2H
- The Diamondbacks hold a 6-5 lead in the season series against the Dodgers this year.
- The Diamondbacks can clinch a season series win over the Dodgers with a victory tonight.
- Arizona has won three of their last four games against Los Angeles entering tonight.
Dodgers vs Diamondbacks Model Projection
Score Projection: Dodgers 5 – Diamondbacks 6
Win Probability: Dodgers 48%, Diamondbacks 52%
Final Thoughts
The Diamondbacks need to keep winning if they want to play baseball in October. Fortunately for them, I think they will get a win tonight to keep the pressure on the Mets and Reds in the Wild Card chase. Los Angeles’ spot in the playoffs is secure, even if their grip on the NL West title is not. And the difference in sense of urgency should be one of the things that helps the Diamondbacks get to Snell and get a win.
